C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/48 (2006.01) C07K 14/52 (2006.01) C07K 14/525 (2006.01) C07K 14/705 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2274498
This invention relates to genes which encode accessory molecule ligands and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived from the tumor necrosis factor family. The chimeric molecules of this invention contain unique properties which lead to the stabilization of their activities and thus greater usefulness in the treatment of diseases. Vectors for expressing genes which encode the molecules of this invention are also discussed.
L'invention porte sur des gènes codant pour des ligands de molécules accessoires et leur utilisation à des fins d'immunomodulation, de vaccination, et de traitement de différentes maladies humaines dont les tumeurs malignes et les maladies auto-immunes. L'invention porte également sur l'emploi de ligands de molécules accessoires constitués de parties de domaines et sous-domaines de molécules dérivées de la famille du facteur de nécrose tumoral. Les molécules chimères de l'invention comportent des propriétés uniques qui conduisent à la stabilisation de leur activité et présentent de ce fait une utilité accrue dans le traitement des maladies. L'invention porte en outre sur des vecteurs exprimant des gènes codant pour les molécules de l'invention.
Cantwell Mark
Kipps Thomas J.
Sharma Sanjai
Smart & Biggar
University Of California
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