C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/395 (2006.01) C07K 14/47 (2006.01) C07K 16/14 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01) C12N 15/31 (2006.01) C12N 15/67 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2227963
Eukaryotic RNA polymerase II holoenzymes that contain RNA polymerase II and one or more regulatory proteins are described. These holoenzymes selectively initiate transcription in vitro when supplemented with general transcription factors. The regulatory proteins act positively and negatively to regulate transcription initiation, at least in part, via functional interactions with RNA polymerase II.
Holoenzymes d'ARN polymérase II eucaryotes contenant de l'ARN polymérase III et une ou plusieurs protéines régulatrices. Ces holoenzymes lancent sélectivement la transcription in vitro lorsqu'elles sont complétées par des facteurs de transcription généraux. Les protéines régulatrices agissent positivement et négativement pour réguler le début de la transcription, au moins en partie, par des interactions fonctionnelles avec l'ARN polymérase II.
Chao David M.
Koleske Anthony J.
Thompson Craig M.
Young Richard A.
Robic
The Whitehead Institute For Biomedical Research
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