C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/15 (2006.01) A61K 38/58 (2006.01) C07K 14/815 (2006.01) C07K 16/38 (2006.01) C07K 16/42 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2203827
The invention relates to novel protease-inhibitors which are obtainable from leeches. It also relates to uses thereof, for instance as a medicament, thus pharmaceutical preparations are provided, as are derivatives, mutants, genes encoding, vectors comprising and cells provided with such genes and/or vectors. In particular the invention relates to a family of proteinaceous protease inhibitors having a molecular weight of about 5.5kD and the following primary sequences DDNCGGKVCSKGQLCHDGHCECTPIRCLIFCPNGFAVDENGCELPCSCKHQ,DDDCGGQVCSKGQLCVDGQCKCTPIRC RIYCPKGFEVDENGCELPCTCLQ,DGNCGGQVCSKGQLCVDGQCKCTPIRCRIYCPKGFEVDENGCELPCTCLQ. This invention also relates to HIV-inhibitors and other therapeutically interesting, low molecular weight, and low antigenic substances from leeches.
Nouveaux inhibiteurs de protéases pouvant être obtenus à partir de sangsues. On décrit également leurs applications, par exemple comme médicament, et on a donc prévu des préparations pharmaceutiques ainsi que des dérivés, des mutants, des gènes les codant, des vecteurs les comportant, et des cellules pourvues de gènes et/ou vecteurs de ce type. Il s'agit notamment d'une famille d'inhibiteurs de protéases protéiques présentant un poids moléculaire de 5,5 kD environ et possédant les séquences primaires DDNCGGKVCSKGQLCHDGHCECTPIRCLIFCPNGFAVDENGCELPCSCKHQ,DDDCGGQVCSKGQLCVDGQCKCTPIRCRIYCPKGFEVDENGCELPCTCLQ,DGNCGGQVCSKGQLCVDGQCKCTPIRCRIYCPKGFEVDENGCELPCTCLQ. On a également prévu des inhibiteurs de VIH et d'autres substances faiblement antigéniques de faible poids moléculaire intéressantes sur le plan thérapeutique et obtenues à partir de sangsues.
Borden Ladner Gervais Llp
Clodica S.a.
Vitaleech Bioscience N.v.
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