Novel farnesyl protein transferase inhibitors as antitumor...

Details Novel farnesyl protein transferase inhibitors as antitumor... Novel farnesyl protein transferase inhibitors as antitumor...

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/415 (2006.01) A61P 35/00 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2535210

Disclosed are novel tricyclic compounds of the formula (I) and a pharmaceutically acceptable salts or solvates thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Also disclosed are uses of the compounds of formula (I) for the manufacture of a medicament for the treatment of cancer.

L'invention concerne de nouveaux composés tricycliques représentés par la formule (I) et des sels ou solvates pharmaceutiquement acceptables de ceux-ci. Ces composés sont utiles pour inhiber la farnésyl protéine transférase. L'invention concerne aussi des compositions pharmaceutiques comprenant les composés représentés par la formule (I), ainsi que l'utilisation desdits composés dans la fabrication d'un médicament pour traiter le cancer.

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