C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/415 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2591705
Disclosed are novel tricyclic compounds of the formula (I) and the pharmaceutically acceptable salts thereof. Y is C or CH. When Y is C then Z is not present and the optional bond from Y to the C-11 carbon of the tricyclic nucleus is present. When Y is CH then Z is present and Z is H or -OH. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising the compounds of formula 1Ø Also disclosed are methods of treating cancer using the compounds of formula 1Ø
La présente invention a trait à de nouveaux composés tricycliques de formule 1.0, dans laquelle: Y est C ou CH; lorsque Y est C, alors Z n'est pas présent et la liaison éventuelle de Y à l'atome de carbone C-11 du noyau tricyclique est présent; lorsque Y est CH, alors Z est présent et Z est H ou OH, ainsi que leurs pharmaceutiquement acceptables. Ces composés sont utiles pour l'inhibition de farnésyl protéine transférase. L'invention a également trait à des compositions pharmaceutiques comportant les composés de formule 1Ø L'invention a trait en outre à des procédés de traitement du cancer mettant en oeuvre les composés de formule 1Ø
Cooper Alan
Desai Jagdish
Wang James J-S
Zhu Hugh
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Schering Corporation
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