Novel fdrg protein and nucleic acid molecules and uses therefor

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C07K 14/435 (2006.01) C07K 14/515 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/22 (2006.01) C12N 1/00 (2006.01) C12N 5/10 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2322425

Novel FDRG polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length FDRG proteins, the invention further provides isolated FDRG fusion proteins, antigenic peptides and anti-FDRG antibodies. The invention also provides FDRG nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a FDRG gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

La présente invention concerne de nouveaux polypeptides, protéines et molécules d'acide nucléique FDRG. Outre des protéines FDRG pleine longueur isolées, la présente invention concerne des protéines de fusion FDRG, des peptides antigéniques et des anticorps anti-FDRG isolés. Elle concerne également des molécules d'acide nucléique FDRG, des vecteurs d'expression recombinés contenant une molécule d'acide nucléique selon la présente invention, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et des animaux transgéniques non humains dans lesquels un gène FDRG a été introduit ou fonctionnellement modifié. Des procédés de diagnostic, de criblage et thérapeutiques faisant appel aux compositions selon la présente invention sont également décrits.

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