C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2511556
The present invention discloses open reading frames (ORFs) in human genome encoding for novel fibrillin-like polypeptides, and reagents related thereto including variants, mutants and fragments of said polypeptides, as well as ligands and antagonists directed against them. The invention provides methods for identifying and making these molecules, for preparing pharmaceutical compositions containing them, and for using them in the diagnosis, prevention and treatment of diseases.
La présente invention concerne des cadres couverts de lecture (ORF) dans un génome humain codant de nouveaux polypeptides de type fibrilline, ainsi que des réactifs associés auxdits cadres comprenant des variants, des mutants et des fragments desdits polypeptides et des ligands ainsi que des antagonistes dirigés contre ceux-ci. L'invention concerne des procédés d'identification et de fabrication de ces molécules en vue de la préparation de compositions pharmaceutiques les contenant et de leur utilisation dans le diagnostic, la prévention et le traitement de maladies.
Bienkowska Jadwiga
Mcallister Gregg
Applied Research Systems Ars Holding N.v.
Borden Ladner Gervais Llp
Laboratoires Serono S.a.
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