C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) A61K 31/70 (2006.01) A61K 38/55 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/00 (2006.01) C07K 14/435 (2006.01) C07K 16/40 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 2224184
The present invention provides for filariid nematode cysteine protease proteins; to filariid nematode cysteine protease nucleic acid molecules, in particular, Dirofilaria immitis L3 larval cysteine protease nucleic acid molecules and Onchocerca volvulus L3 larval cysteine protease nucleic acid molecules; to antibodies raised against such proteins, and to compounds that inhibit filariid nematode cysteine protease activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies and/or inhibitors. The present invention also includes therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitors, and the use of such compositions to protect an animal from disease caused by parasitic helminths.
Protéines de protéase de cystéine de nématodes filariides, molécules d'acide nucléique de protéase de cystéine de nématodes filariides, en particulier, molécules d'acide nucléique de protéase de cystéine larvaire de Dirofilaria immitis L3 et molécules d'acide nucléique de protéase de cystéine larvaire d'Onchocerca volvulus L3; anticorps dirigés contre ces protéines, et composés inhibant l'activité de la protéase de cystéine des nématodes filariides. L'invention concerne également des procédés permettant d'obtenir ces protéines, molécules d'acide nucléiques, anticorps et/ou inhibiteurs. Sont également décrites des compositions thérapeutiques contenant ces protéines, molécules d'acide nucléique, anticorps et/ou inhibiteurs, et l'utilisation de ces compositions pour protéger un animal contre la maladie provoquée par des helminthes parasitaires.
Frank Glenn R.
Grieve Robert B.
Tripp Cynthia Ann
Wisnewski Nancy
Colorado State University Research Foundation
Heska Corporation
Johnson Ernest Peter
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