Novel fka-25 substance having inhibitory action against...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 405/06 (2006.01) A61K 31/403 (2006.01) C12P 17/16 (2006.01)

Patent

CA 2461942

The present invention relates to a novel FKA-25 substance, which inhibits formation of the foam macrophage originated from mouse, having inhibitory action against formation of the foam macrophage and a process for production thereof. The process includes culturing Pseudobotrytis sp. FKA-25 belonging to genus Pseudobotrytis sp. and having ability to produce FKA-25 substance in a medium, accumulating FKA-25 substance in the cultured medium, and collecting FKA-25 substance from the cultured mass. The obtained FKA-25 substance specifically inhibits the formation of the foam macrophage originated from mouse and is expected to be useful for prevention and treatment of arteriosclerosis and causative diseases therefrom.

L'invention concerne un nouvel inhibiteur de la formation de cellules spumeuses de macrophages, FKA-25, qui est une matière inhibant la formation de cellules spumeuses de macrophages de souris. Pseudobotrytis sp. FKA-25, une souche appartenant au genre Pseudobotrytis et qui peut produire FKA-25, est cultivée dans un milieu de culture permettant l'accumulation de FKA-25, cette matière étant ensuite extraite dudit milieu. En raison de sa capacité à inhiber spécifiquement la formation de cellules spumeuses de macrophages de souris, FKA-25 est susceptible d'être utile dans la prévention et le traitement de l'artériosclérose et de maladies engendrées par celle-ci.

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