C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 493/14 (2006.01) A23L 1/30 (2006.01) A23L 2/00 (2006.01) A61K 8/49 (2006.01) A61K 31/353 (2006.01) A61P 37/08 (2006.01)
Patent
CA 2491027
The present invention relates to novel flavone C-glycoside derivatives or salts thereof, especially those showing an anti-allergic effect, and compositions containing them. Recently, cases of allergic diseases, especially pollenosis and atopic dermatitis have increased to such a degree that they have become a social problem. Flavones and their glycosides have been reported to have the effect of inhibiting histamine release from mast cells or an immunosuppressive effect and expected for application as allergy therapies. However, most flavones exhibit their effects only at high doses, so that effective compounds at lower doses are highly desired. The present invention provides novel components capable of treating allergic diseases at low doses and compositions containing them.
L'invention concerne un nouveau dérivé de flavone C-glycoside, ou son sel, qui exerce en particulier un effet antiallergique, ainsi qu'une composition qui renferme ce nouveau dérivé. Les maladies allergiques se sont beaucoup développées ces dernières années, viennent en tête la pollinose et la dermatite atopique qui enregistrent une nette recrudescence, ce qui entraîne de nombreux problèmes sociaux. Les flavones et leurs glycosides, lesquels exerceraient un effet inhibiteur sur la libération de l'histamine par les adipocytes ainsi qu'un effet immunosuppresseur, sont censés être utilisés comme traitements antiallergiques. Cependant, comme les flavones doivent être pris en quantités importantes pour exercer leurs effets, le besoin urgent de trouver un composant qui exercerait les mêmes effets mais avec une dose inférieure s'est fait ressentir. L'invention a ainsi pour but de fournir un nouveau composant qui permet de traiter, à faible dose, les troubles allergiques, ainsi qu'une composition qui renferme ce composant.
Ishikura Yoshiyuki
Nukaya Haruo
Tsuji Kuniro
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Suntory Holdings Limited
Suntory Limited
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