Novel forms of...

Details Novel forms of... Novel forms of...

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01)

Patent

CA 2672554

Novel forms of [R-(R*,R*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1- methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt designated Form XX, Form XXI, Form XXII, Form XXIII, Form XXIV, Form XXV, Form XXVI, Form XXVII, Form XXVIII, Form XXIX, and Form XXX, characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia (BPH) and Alzheimer's disease.

De nouvelles formes d'un sel d'hémicalcium de l'acide ¬R-(R*,R*)|-2-(4-fluorophényl)-.bêta.,.delta.-dihydroxy-5-(1-méthyléthyl)-3-phényl-4-¬(phényla mino) carbonyl|-1H-pyrrole-1-heptanoïque, appelé forme XX, forme XXI, forme XXII, forme XXIII, forme XXIV, forme XXV, forme XXVI, forme XXVII, forme XXVIII, forme XXIX et forme XXX, caractérisées par une diffraction aux rayons X réalisée sur la substance en poudre, une RMN à l'état solide et/ou une spectrocopie Raman sont décrites, de même que des méthodes permettant de préparer des compositions pharmaceutiques à base de ces formes, utiles en tant qu'agents destinés à traiter l'hyperlipidémie, l'hypercholestérolémie, l'ostéoporose, l'hyperplasie bénigne de la prostate et la maladie d'Alzheimer.

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