Novel forms of pravastatin sodium

C - Chemistry – Metallurgy – 07 – C

Patent

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C07C 69/732 (2006.01) A61K 9/14 (2006.01) A61K 31/215 (2006.01) A61K 31/22 (2006.01) A61P 3/06 (2006.01) A61P 9/10 (2006.01) C07C 67/00 (2006.01) C07C 67/52 (2006.01) C07C 69/33 (2006.01)

Patent

CA 2394200

New polymorphic forms of pravastatin sodium are provided. Each of the new forms is selectively obtained by crystallization from different solvent systems, each solvent system having a protic component, and by controlling the rate of crystallization through temperature. The new polymorphic forms are suitable for use as active substances of pharmaceutical dosage forms for reduction of serum cholesterol levels in the bloodstream.

L'invention concerne de nouvelles formes polymorphes de pravastatine sodique. On prépare sélectivement chacune de ces nouvelles formes au moyen d'une cristallisation à partir de différents systèmes de solvants, ces système de solvants contenant chacun un composant protique, et en modulant la vitesse de cristallisation par une régulation de la température. Ces nouvelles formes polymorphes peuvent être utilisées en tant que principes actifs dans des formes posologiques pharmaceutiques destinées à abaisser les taux de cholestérol sérique dans le sang.

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