Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl)-.beta.,...

Details Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl)-.beta.,... Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl)-.beta.,...

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01)

Patent

CA 2573771

Novel forms of [R-(R*,R*)]-2-(4-fluorophenyl)-.beta.,.delta.-dihydroxy-5-(1- methylethyl)-3-phenyl-4~[(phenylamino)carbonyl]-1 H-pyrrole-1 -heptanoic acid hemi calcium salt designated Form XX, Form XXI, Form XXII, Form XXIII, Form XXIV, Form XXV, Form XXVI, Form XXVII, Form XXVIII, Form XXIX, and Form XXX, characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia (BPH) and Alzheimer's disease.

L'invention porte sur de nouvelles formes de [R-(R*,R*)]-2-(4-fluorophenyl)-ß,d-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1 H-pyrrole-1 acide heptanoïque hemi sel de calcium désignées par Forme XX, Forme XXI, Forme XXII, Forme XXIII, Forme XXIV, Forme XXV, Forme XXVI, Forme XXVII, Forme XXVIII, Forme XXIX, et Forme XXX, et caractérisées par leur diffraction des poudres aux rayons W, par RNM à l'état solide, et/ou la spectrométrie Raman. L'invention concerne aussi des procédés de préparation de ces forme et des compositions pharmaceutiques les contenant, qui sont utiles en tant qu'agents dans le traitement de l'hyperlipidémie, hypercholestérolémie, l'hyperplasie prostatique bénigne et la maladie d'Alzheimer.

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