A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/48 (2006.01) A61P 3/04 (2006.01)
Patent
CA 2376217
The present invention is directed to a semi-solid formulation comprising a lipid-regulating agent. Said formulation is prepared by solubilizing said lipid-regulating agent in one or more liquid components to form a clear liquid solution, then solidifying said solution by adding one or more solid or semi- solid components to said solution to form a semi-solid formulation. Said formulation can melt or dissolve upon mixing with a bulk aqueous medium. The resulting formulation results in an increase in drug solubility and oral bioavailability, and an improved dissolution rate.
La présente invention concerne une préparation semi-solide refermant un agent de régulation lipidique. Cette préparation s'obtient en solubilisant ledit agent de régulation lipidique dans un ou plusieurs composés liquides pour former une solution liquide claire, puis en solidifiant ladite solution par adjonction d'un ou de plusieurs composés solides ou semi-solides de manière à obtenir une formulation semi-solide. Ladite formulation peut fondre ou se dissoudre lorsqu'on la mélange à un support aqueux brut. La préparation qui en résulte se caractérise par une solubilité et une biodisponibilité orale accrues, ainsi que par un taux de dissolution plus favorable.
Hansrani Pawan
Liu Rong (ron)
Pan Qinghai
Abbott Laboratories
Torys Llp
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