A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/4439 (2006.01) A61K 33/00 (2006.01) A61P 1/04 (2006.01)
Patent
CA 2665226
The present invention relates to combinations of a proton pump inhibiting agent and at least one buffering agent that have been found to possess improved bioavailability, chemical stability, physical stability, dissolution profiles, disintegration times, as well as other improved pharmacokinetic, pharmacodynamic, chemical and/or physical properties. The present invention is directed to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a gastrointestinal disorder or disease including nocturnal acid breakthrough, or the symptoms associated therewith
La présente invention concerne les combinaisons d'un agent inhibiteur de pompe à protons et d'au moins un agent tampon qui se sont avérés posséder des caractéristiques améliorées en termes de biodisponibilité, de stabilité chimique, de stabilité physique, de profils de dissolution, de temps de désintégration, de même que d'autres propriétés pharmacocinétiques, pharmacodynamiques, chimiques et/ou physiques améliorées. La présente invention concerne des procédés, des kits, des combinaisons et des compositions pour traiter, prévenir ou réduire le risque de développer un trouble gastro-intestinal ou une maladie comprenant une sécrétion d'acide nocturne, ou les symptômes associés à celle-ci.
Bowe Craig
Gallo Laura
Hall Warren
Olmstead Kay
Weston Laura
Santarus Inc.
Smart & Biggar
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