Novel full-length genomic rna of japanese encephalitis...

Details Novel full-length genomic rna of japanese encephalitis... Novel full-length genomic rna of japanese encephalitis...

C - Chemistry, Metallurgy

12

N

C12N 15/40 (2006.01)

Patent

CA 2501289

The present invention relates to a novel genomic RNA of Japanese encephalitis virus (JEV) and an infectious JEV cDNA therefrom. Particularly, the present invention relates to a full-length genomic RNA of JEV represented by SEQ. ID. No 15 and an infectious JEV cDNA therefrom. JEV genomic RNA and infectious JEV cDNA of the present invention can be used not only for the identification of the JEV genes, but also for the molecular biological studies including JEV replication, transcription, and translation. Moreover, they can also be applied to the development of the therapeutic agents, vaccines, diagnostic reagents, and diagnostic devices for Japanese encephalitis, and can be used as an expression vector for the various foreign genes.

l'invention concerne un ARN génomique du virus de l'encéphalite japonaise (JEV) et un ADNc de JEV infectieux correspondant. Plus particulièrement, cette invention concerne un ARN génomique pleine longueur de JEV représenté par la SEQ. ID. No 15 et l'ADNc de JEV infectieux correspondant. L'ARN génomique de JEV et l'ADNc de JEV infectieux correspondant. L'ARN génomique de JEV et l'ADNc de JEV infectieux de cette invention peuvent être utilisés non seulement dans l'identification de gènes de JEV, mais également dans des études biologiques moléculaires notamment la réplication, la transcription et la translation de JEV. En outre, ils peuvent également être appliqués au développement d'agents thérapeutiques, de vaccins, de réactifs diagnostics, et de dispositifs destinés au diagnostic de l'encéphalite japonaise, ainsi que comme vecteurs d'expression pour divers gènes étrangers.

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