C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/4188 (2006.01) A61P 35/00 (2006.01) C07D 471/04 (2006.01) C07D 513/04 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2517933
Novel fused heteroaromatic compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-.szlig. signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
Nouveaux composés hétéroaromatiques condensés ainsi que leurs dérivés, intermédiaires destinés à leur préparation, compositions pharmaceutiques les contenant et leur utilisation comme médicaments. Les composés selon la présente invention sont des inhibiteurs puissants de la voie de transmission de signal du facteur de croissance transformant (TGF)-.beta.. Ils sont utiles dans le traitement de divers états pathologiques associés au TGF, tels que le cancer et les affections de type fibreuses.
Blumberg Laura Cook
Munchhof Michael John
Shavnya Andre
Pfizer Products Inc.
Smart & Biggar
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