C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/85 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) C07D 209/42 (2006.01) C07D 307/84 (2006.01) C07D 333/62 (2006.01) C07D 333/68 (2006.01) C07D 333/70 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01) C08B 37/16 (2006.01)
Patent
CA 2168858
A novel carboxylic acid compound having a condensed ring, which is represented by the formula (I) Image (I) wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition thereof and pharmaceutical use thereof. The novel carboxylic acid compound having a condensed ring and pharma- cologically acceptable salt thereof of the present invention have superior GPIIb/IIIa antagonism in mammals inclusive of human; can be administered orally; have long life in blood and low toxicity; and show less side-effects. Accordingly, they are extremely useful for the prophylaxis and treatment of thrombotic diseases and other diseases.
Nouveau composé d'acide carboxylique à noyau fusionné représenté par la formule générale (I) (dans laquelle chaque symbole est tel que défini dans la spécification) ou sel de ce composé acceptable en pharmacologie; composition médicinale contenant ce composé, et son utilisation en médecine. Ce composé et ce sel présentent un excellent antagonisme GPIIb/IIIa contre les mammifères, y compris l'homme, peuvent être administrés oralement, présentent une longue durée de vie dans le sang et une faible toxicité, ainsi que des effets secondaires limités. Ils peuvent être utilisés avantageusement dans la prévention ou le traitement des maladies thrombotiques.
Ashimori Atsuyuki
Ebisu Hajime
Eda Masahiro
Ikegawa Ruriko
Imada Teruaki
Fetherstonhaugh & Co.
The Green Cross Corporation
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