Novel fusion proteins and use thereof for preparing...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 7/04 (2006.01) A61K 39/29 (2006.01) A61K 39/295 (2006.01) C07K 14/02 (2006.01) C07K 14/18 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2728233

The present invention relates to an immunogenic fusion protein which comprises at least, on the C-terminal side, a first peptide constituted of the S protein deleted of the transmembrane domain thereof located at the N-terminal end thereof, of a hepatitis B virus (HBV) isolate, and on the N-terminal side, a second peptide constituted of the transmembrane domain and of the ectodomain of at least one envelope protein of a hepatitis C virus (HCV) isolate. The subject matter of the invention is also a hybrid nucleic acid molecule encoding said fusion protein, and also a vector comprising said hybrid nucleic acid molecule, a subviral particle comprising said fusion protein, an immunogenic composition comprising at least said fusion protein, or at least said hybrid nucleic acid molecule, or at least said subviral particle, and a cell line for the production of said fusion protein, or of said hybrid nucleic acid molecule, or of said subviral particle.

La présente invention concerne une protéine de fusion immunogène qui comprend au moins du côté C-terminal, un premier peptide constitué de la protéine S délétée de son domaine transmembranaire situé à son extrémité N-terminale d'un isolât du virus de l'hépatite B (HBV), et du côté N-terminal, un second peptide constitué du domaine transmembranaire et de l'ectodomaine d'au moins une protéine d'enveloppe d'un isolât du virus de l'hépatite C (HCV). L'invention a également pour objet une molécule d'acides nucléiques hybride codant ladite protéine de fusion, ainsi qu'un vecteur comprenant ladite molécule d'acides nucléiques hybride, une particule sous virale comprenant ladite protéine de fusion, une composition immunogène comprenant au moins ladite protéine de fusion, ou au moins ladite molécule d'acides nucléiques hybride, ou au moins ladite particule sous-virale, et une lignée cellulaire pour la production de ladite protéine de fusion, ou de ladite molécule d'acides nucléiques hybride, ou de ladite particule sous-virale.

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