Novel g-protein coupled receptor (h7tba62)

Details Novel g-protein coupled receptor (h7tba62) Novel g-protein coupled receptor (h7tba62)

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2239605

H7TBA62 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing H7TBA62 polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HIV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis, angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

Polypeptides et polynucléotides H7TBA62 et méthodes de production des ces polypeptides par des techniques recombinantes. Sont aussi divulguées des méthodes pour l'usage de polypeptides et de polynucléotides H7TBA62 dans la conception de protocoles pour le traitement d'infections dues à des bactéries, des champignons, des protozoaires et des virus, en particulier les infections dues au VIH-1 ou au VIH-2 et le traitement de la douleur, des cancers, de l'anorexie mentale, de la boulimie, de l'asthme, de la maladie de Parkinson, de l'insuffisance cardiaque aiguë, de l'hypotension, de l'hypertension, de la rétention urinaire, de l'ostéoporose, de l'angine de poitrine, de l'infarctus du myocarde, des ulcères de l'asthme, des allergies, de l'hypertrophie bénigne de la prostate et des troubles psychotiques et neurologiques, dont l'anxiété, la schizophrénie, le trouble bipolaire, le délire, la démence, le retard mental sévère et les dyskinésies, comme la maladie de Huntington ou le syndrome de Gilles de la Tourette, notamment, et pour les test diagnostiques pour ces troubles.

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