Novel g-protein coupled receptor (hfgan72x)

Details Novel g-protein coupled receptor (hfgan72x) Novel g-protein coupled receptor (hfgan72x)

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2231748

HFGAN72X polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HFGAN72X polypeptides and polynucleotides in the design of protocols for the treatment of infections such as bacterial, fungal, protozoan and viral infections, particularly infections caused by HIV-1 or HFV-2; pain; cancers; anorexia; bulimia; asthma; Parkinson's disease; acute heart failure; hypotension; hypertension; urinary retention; osteoporosis; angina pectoris; myocardial infarction; ulcers; asthma; allergies; benign prostatic hypertrophy; and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, severe mental retardation and dyskinesias, such as Huntington's disease or Gilles dela Tourett's syndrome, among others and diagnostic assays for such conditions.

Polypeptides et polynucléotides HFGAN72X et méthodes pour produire ces polypeptides par recombinaison. L'invention concerne également des méthodes pour utiliser les polypeptides et polynucléotides HFGAN72X dans l'élaboration de protocoles de traitement pour les infections, notamment les infections causées par des bactéries, des champignons, des protozoaires et des virus et en particulier les infections à VIH-1 ou à VHF-2; pour la douleur; les cancers; l'anorexie; la boulimie; l'asthme; la maladie de Parkinson; l'insuffisance cardiaque aiguë; l'hypotension; l'hypertension; la rétention urinaire; l'ostéoporose; l'angine de poitrine; l'infarctus du myocarde; les ulcères; les allergies; l'hypertrophie bénigne de la prostate; et les troubles neurologiques et psychotiques, dont l'anxiété, la schizophrénie, la psychose maniaque-dépressive, le delirium, la démence, le retard mental grave et les dyskinésies, telles que la maladie de Huntington ou de Gilles de la Tourette, entre autres, et des tests diagnostiques pour ces affections.

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