Novel g protein-coupled receptor protein and dna thereof

Details Novel g protein-coupled receptor protein and dna thereof Novel g protein-coupled receptor protein and dna thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 45/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/12 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2382889

A human brain-origin protein (a G protein-coupled receptor protein) or its salt; a DNA encoding this protein; a method of determining a ligand to this protein; a method/kit for screening a compound (for example, an agonist, an antagonist) capable of altering the binding properties of the ligand to the protein; a compound obtained by the screening or its salt, etc. The human brain-origin protein as described above or the DNA encoding the same can be used in preventives and/or remedies for diseases in association with the dysfunction of the protein.

L'invention concerne une protéine humaine d'origine cérébrale (protéine réceptrice couplée à une protéine G) ou ses sels; un ADN codant pour cette protéine; un procédé permettant de déterminer un ligand pour ladite protéine; un procédé/kit permettant de cribler un composé (par exemple, un agoniste, un antagoniste) capable de modifier les propriétés de liaison du ligand à la protéine; un composé obtenu au moyen du criblage de ladite protéine ou de ses sels, etc. La protéine humaine d'origine cérébrale précitée ou l'ADN codant pour cette protéine peuvent être utilisés pour prévenir ou guérir des maladies associées au dysfonctionnement de cette protéine.

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