Novel g protein-coupled receptor protein and dna thereof

Details Novel g protein-coupled receptor protein and dna thereof Novel g protein-coupled receptor protein and dna thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 1/21 (2006.01) C12P 21/02 (2006.01) C12Q 1/06 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2344459

A human-origin G protein-coupled receptor protein or its peptide fragment or its salt, a nucleic acid encoding this receptor protein and its derivative, etc. The human hippocampus-origin G protein-coupled receptor protein or the nucleic acid encoding the same and its derivative are usable in determining a ligand (an agonist) to the G protein-coupled receptor protein, as preventives and/or remedies for diseases in association with dysfunction of the G protein- coupled receptor protein, as gene diagnostics, in a method for screening a compound capable of varying the expression dose of the G protein-coupled receptor protein or its peptide fragment, etc.

L'invention porte sur une nouvelle protéine réceptrice couplée à la protéine G d'origine humaine ou l'un de ses fragments peptidiques, ou ses sels, sur l'acide nucléique codant pour cette protéine réceptrice et ses dérivés, etc. Ladite protéine réceptrice extraite de l'hippocampe humain ou l'acide nucléique codant pour elle et ses dérivés, servent à élaborer un ligand (agoniste) de cette même protéine réceptrice utilisable pour prévenir ou traiter les maladies associées aux disfonctions de cette même protéine réceptrice, pour des diagnostics géniques, ou pour le criblage de composés susceptibles de modifier la dose exprimée par ladite protéine réceptrice ou des fragments peptidiques.

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