C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2321193
DNA encoding a novel human GABAB receptor subunit, HG20, as well as the protein encoded by the DNA, is provided. Also provided is DNA encoding a novel murine GABAB receptor subunit, GABABR1a, as well as the protein encoded by the DNA. Heterodimers of HG20 protein and GABABR1a protein that form a functional GABAB receptor are disclosed. Methods of identifying agonists and antagonists of the GABAB receptor are also provided.
La présente invention concerne de l'ADN codant une nouvelle sous-unité du récepteur GABA¿B? humain, HG20, ainsi que la protéine codée par ledit ADN. Elle concerne également un ADN codant une nouvelle sous-unité de récepteur GABA¿B? murin, GABA¿B?R1a, ainsi que la protéine codée par ledit ADN. Elle concerne encore des hétérodimères de la protéine HG20 et de la protéine GABA¿B?R1a qui forment un récepteur GABA¿B? fonctionnel, ainsi que des procédés d'identification d'agonistes et d'antagonistes du récepteur GABA¿B?.
Bonner Tom I.
Bonnert Timothy P.
Clark Janet
Kolakowski Lee F. Jr.
Liu Qingyun
Board Of Regents The University Of Texas System
Merck & Co. Inc.
Merck Frosst Canada & Co.
National Institutes Of Health
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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