A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01)
Patent
CA 2519962
The invention relates to a novel galenical system for taste masking, protecting an active substance, in particular in an acid medium, modulating releasing properties, masking mucous irritability and toxicity of certain active substances, for preparing aqueous forms which have a masked taste, are stable and pH independent. Said invention also relates, in particular to a galenical system which is embodied in the form of lipidic solid particles and strictly hydrophobic and devoid of water, surface active agents, emulsifiers, solvent traces and which is characterised in that it comprises at least one type of hydrophobic wax and at least one type of fatty non-neutralised acid.
L'invention propose un nouveau système galénique permettant le masquage du goût, la protection du principe actif, particulièrement en milieu acide, la possibilité de modulation des propriétés de libération, le masquage des effets d'irritabilité mucosale et de la toxicité de certains principes actifs, la préparation de formes aqueuses, à goût masqué, stables et pH indépendantes. Particulièrement, l'invention a pour objet un système galénique, sous forme de particules lipidiques solides, strictement hydrophobes ne contenant strictement pas d'eau, ni de tensioactifs, ni d'agents émulsionnants, ni de traces de solvants, caractérisé en ce qu'il comprend au moins une cire hydrophobe et au moins un acide gras non neutralisé.
Ioualalen Karim
Raynal Rose Anne
Capsugel France
Gowling Lafleur Henderson Llp
Oralance Pharma
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