C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2493263
Novel polypeptide whose incidence rate is higher in the synovial tissue of human rheumatoid arthritis (RA) patients than in the synovial tissue of human osteoarthritis (OA) patients; a polynucleotide coding for the polypeptide; a vector comprising the polynucleotide; a transformant cell comprising the vector; and an antibody to the polypeptide. Further, there are disclosed a polynucleotide having at least 15 bases which specifically hybridizes with the polynucleotide; a testing method useful for diagnosis of RA; and a testing kit useful for diagnosis of RA.
L'invention concerne un nouveau polypeptide dont le taux d'incidence est plus important dans le tissu synovial de patients humains atteints d'arthrite rhumatoïde (RA) que dans le tissu synovial de patients humains atteints d'ostéoarthrite (OA). L'invention concerne également un polynucléotide codant pour ce polypeptide; un vecteur comprenant le polynucléotide; une cellule transformante comprenant le vecteur; et un anticorps dirigé contre le polypeptide. En outre, cette invention concerne un polynucléotide présentant au moins 15 bases, lequel s'hybride spécifiquement avec le polynucléotide; un procédé et une trousse de test permettant le diagnostic de l'arthrite rhumatoïde.
Akamatsu Masahiko
Harigai Masayoshi
Takasaki Jun
Takeuchi Masahiro
Tsunoyama Kazuhisa
Astellas Pharma Inc.
Dennison Associates
Harigai Masayoshi
Yamanouchi Pharmaceutical Co. Ltd.
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