C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/10 (2006.01) C12N 5/0735 (2010.01) A61K 45/00 (2006.01) C12N 15/63 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) A01K 67/027 (2006.01) C40B 30/00 (2006.01)
Patent
CA 2550117
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
L'invention concerne des animaux transgéniques, ainsi que des compositions et des procédés associés ayant trait à la caractérisation de la fonction génique. L'invention concerne en particulier des souris transgéniques présentant des disruptions dans les gènes PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 ou PRO1801. Ces études et caractérisations in vivo permettent de découvrir ou d'identifier de manière fiable des agents thérapeutiques et/ou des traitements utiles dans la prévention, l'atténuation ou le traitement de maladies ou dysfonctionnements associés à des disruptions géniques, tels que les troubles neurologiques, les troubles cardio-vasculaires, endothéliaux ou angiogéniques, les anomalies oculaires, les troubles immunologiques, les troubles oncologiques, les anomalies ou troubles métaboliques osseux, les troubles métaboliques lipidiques ou les troubles de croissance.
Anderson Stephen
Brennan Jane
Desauvage Frederic
Ding Zhiyong
Edwards Joel
Genentech Inc.
Lexicon Genetics Incorporated
Lexicon Pharmaceuticals Inc.
Smart & Biggar
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