Novel genes and markers associated to type 2 diabetes mellitus

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/68 (2006.01)

Patent

CA 2593473

Genes, SNP markers and haplotypes of susceptibility or predisposition to T2D and subdiagnosis of T2D are disclosed. Methods for diagnosis, prediction of clinical course and efficacy of treatments for T2D using polymorphisms in the T2D risk genes are also disclosed. The genes, gene products and agents of the invention are also useful for monitoring the effectiveness of prevention and treatment of T2D. Kits are also provided for the diagnosis, selecting treatment and assessing prognosis of T2D.

La présente invention décrit des gènes, des marqueurs SNP et des haplotypes de sensibilité ou de prédisposition au DT2 et de sous-diagnostic du DT2. Des procédés de diagnostic, de prédiction de l'évolution clinique et de l'efficacité de traitements du DT2 utilisant des polymorphismes dans les gènes de prédisposition au DT2 sont également décrits. Les gènes, produits de gènes et agents de l'invention sont également utiles pour contrôler l'efficacité de la prévention et du traitement du DT2. L'invention concerne en outre des kits pour le diagnostic, la sélection du traitement et l'évaluation du pronostic du DT2.

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