C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/4164 (2006.01) C07D 233/54 (2006.01) C07D 235/06 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01) C12N 9/10 (2006.01)
Patent
CA 2663635
The present invention relates to novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuring cyclase activity, and for determining the inhibitory activity of compounds against these glutaminyl cyclase isoenzymes.
La présente invention concerne des protéines similaires aux glutaminyl-cyclotransférases (Glutaminyl-Peptide Cyclotransferase-Like : QPCTL) innovantes, qui sont des isoenzymes de la glutaminyl-cyclase (QC, EC 2.3.2.5), ainsi que des acides nucléiques isolés qui codent pour ces isoenzymes, tous ces produits étant utilisables pour la découverte de nouveaux agents thérapeutiques, pour la mesure de l'activité cyclase et pour la détermination de l'activité inhibitrice de composés contre ces isoenzymes de la glutaminyl-cyclase.
Cynis Holger
Demuth Hans-Ulrich
Rahfeld Jens-Ulrich
Schilling Stephan
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Probiodrug Ag
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