C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/38 (2006.01) A61K 31/18 (2006.01) A61K 31/27 (2006.01) A61K 31/66 (2006.01) A61K 31/662 (2006.01) C07C 211/21 (2006.01) C07C 239/20 (2006.01) C07C 307/04 (2006.01) C07C 307/06 (2006.01) C07F 9/40 (2006.01)
Patent
CA 2238389
The present invention relates to novel geranylgeranyl-derivatives and the pharmaceutically acceptable salts thereof having antiproliferative acitivity in eukaryotic cells with respect to the inhibition of protein geranylgeranylation. The invention also relates to the pharmaceutical compositions containing the novel derivatives and to the process for the preparation thereof.
L'invention concerne des dérivés géranyl-géranyle et leurs sels acceptables sur le plan pharmaceutique. Ces dérivés ont une activité antiproliférative vis-à-vis des cellules eukaryotes, l'inhibition intervenant par la géranyl-géranylation de protéines. L'invention concerne également des compositions pharmaceutiques contenant le nouveau dérivé et le procédé de préparation de celui-ci.
Baldacci Massimo
Balsamo Aldo
Danesi Romano
Del Tacca Mario
Macchia Bruno
Laboratori Baldacci S.p.a.
Riches Mckenzie & Herbert Llp
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