A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 38/26 (2006.01) A61K 38/38 (2006.01) A61P 3/10 (2006.01) C07K 14/47 (2006.01) C07K 14/605 (2006.01) C07K 14/765 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2550050
The present invention relates to a compound having the structure of the formula (I) : GLP-1 agonist-L-RR-protraction protein (I) wherein GLP-1 agonist is a polypeptide which is an agonist of the human GLP-1 receptor, L is a linker connecting an amino acid side chain of said GLP-1 agonist with RR, RR is the remains of a reactive residue that has formed a covalent bond with an amino acid residue of the protraction protein, and protraction protein is a protein having a molar weight of at least 5 kDa, having a plasma halflife of at least 24 hours in human plasma , and said protraction protein has been synthesised by a non-mammalian organism or synthetically.
La présente invention a trait à de nouveaux agonistes GLP-1 prolongés par couplage à une protéine de protraction
Hansen Thomas Kruse
Lau Jesper
Madsen Kjeld
Schiodt Christine Bruun
Svendsen Anne
Dimock Stratton Llp
Novo Nordisk A/s
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