Novel glutamate receptor modulatory proteins and nucleic...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) G01N 33/94 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2432280

Novel mGluR5M polypeptides, proteins, and nucleic acid molecules are disclosed. In additions to isolated, full-length mGluR5M proteins, the invention further provides isolated mGluR5M fusion proteins, antigenic peptides and anti-mGluR5M antibodies. The invent ion also provides mGluR5M nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals in which a mGluR5M gene has been introduced or disrupted. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.

L'invention concerne de nouveaux polypeptides, protéines, et molécules d'acides nucléiques mGluR5M. En plus des protéines mGluR5M pleine longueur isolées, l'invention concerne des protéines de fusion mGluR5M isolées, des peptides antigéniques et des anticorps anti-mGluR5M. Par ailleurs, l'invention concerne des molécules d'acides nucléiques mGluR5M, des vecteurs d'expression recombinants contenant une molécule d'acides nucléiques de l'invention, des cellules hôtes dans lesquelles ont a introduit les vecteurs d'expression et des animaux transgéniques non humains dans lesquels un gène mGluR5M a été introduit ou dissocié. Enfin, l'invention concerne des méthodes diagnostiques, thérapeutiques et de criblage faisant intervenir les compositions de l'invention.

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