C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/18 (2006.01) C07H 21/04 (2006.01) C12N 7/00 (2006.01) C12N 15/00 (2006.01) C12P 21/04 (2006.01) C12P 21/06 (2006.01)
Patent
CA 2610164
The invention relates to a novel Glutamic Acid Decarboxylase (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Parkinson's disease, Alzheimer's disease, epilepsy, and the like, using viral and non-viral delivery systems that deliver therapeutic agents to specific regions of the brain. More specifically, using an adeno-associated viral vector to deliver a nucleotide sequence encoding a novel glutamic acid decarboxylase (GAD) to specific regions of the brain that are over stimulated or disinhibited in various diseases, including neurodegenerative diseases.
L'invention concerne une nouvelle décarboxylase d'acide glutamique (GAD). En particulier, l'invention concerne de nouvelles séquences d'ADN et de protéines associées à GAD. En outre, l'invention concerne une nouvelle composition et des méthodes associées pour traiter des maladies neurodégénératives, notamment la maladie de Parkinson, la maladie d'Alzheimer, l'épilepsie et analogue, au moyen de systèmes d'administration viraux et non viraux administrant des agents thérapeutiques dans des zones spécifiques du cerveau. En particulier, l'invention concerne l'utilisation d'un vecteur viral adéno-associé à administrer à une séquence nucléotidique codant une nouvelle décarboxylase d'acide glutamique (GAD) dans des zones spécifiques du cerveau qui sont sur-stimulées ou désinhibées dans des maladies variées, notamment des maladies neurodégénératives.
Bland Ross
During Matthew
Fitzsimons Helen
Kaplitt Michael
Neurologix Inc.
Riches Mckenzie & Herbert Llp
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