Novel glycoproteins and methods of use thereof

Details Novel glycoproteins and methods of use thereof Novel glycoproteins and methods of use thereof

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) C07K 14/59 (2006.01)

Patent

CA 2417141

The present invention provides novel isolated ARP/BRP polynucleotides and the membrane-associated or secreted polypeptides encoded by the ARP/BRP polynucleotides. Also provided are ARP and BRP protein multimers. Further provided are the antibodies that immunospecifically bind to a ARP/BRP polypeptide or any derivative, variant, mutant or fragment of the ARP/BRP polypeptide, a ARP/BRP multimer polynucleotide or antibody. The invention additionally provides methods in which the ARP/BRP polypeptide, multimer, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, e.g. reproductive disorder, as well as to other uses.

L'invention concerne des polynucléotides isolés à affinité alpha/bêta appelés ARP/BRP (alpha-related/beta-related proteins) et les polypeptides associés à la membrane ou sécrétés qui sont codés par les polynucléotides ARP/BRP en question. L'invention concerne également des multimères de protéine ARP et BRP. L'invention concerne par ailleurs des anticorps à liaison immunospécifique sur polypeptide ARP/BRP (y compris un dérivé, variant, mutant ou fragment quelconque de polypeptide ARP/BRP), multimère, polynucléotide ou anticorps ARP/BRP. Enfin, l'invention concerne des procédés permettant d'utiliser le polypeptide,multimère, polynucléotide ou anticorps ARP/BRP dans la détection et le traitement d'un large éventail d'états pathologiques, comme par exemple les troubles de la reproduction, et pour d'autres applications.

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