Novel glycosphingolipids and the use thereof

Details Novel glycosphingolipids and the use thereof Novel glycosphingolipids and the use thereof

C - Chemistry, Metallurgy

07

H

C07H 15/04 (2006.01) A61K 31/70 (2006.01) C07H 15/10 (2006.01) C12P 19/44 (2006.01)

Patent

CA 2116442

The present invention relates to the novel glycosphingolipid represented by the formula (A): (see formula I) wherein R represents (see formula II), where R2 represents H or OH and X denotes an integer of 0-26, or -(CH2)7CH=CH(CH2)7CH3 and R1 represents any one of the substituents defined by the following (a)-(e): (a) -CH2(CH2)Y CH3. (b) -CH(OH)(CH2)Y CH3, (c) -CH(OH)(CH2)Y CH(CH3)2, (d) -CH=CH(CH2)Y CH3, and (e) -CH(OH)(CH2)Y CH(CH3)CH2CH3, wherein Y denotes an integer of 5-17. The present invention also relates to an anti-tumor agent and an immunostimulator comprising one or more of the aforementioned compounds as effective ingredients. Furthermore, the present invention relates to a process for preparing a glycosphingolipid, characterized in that a particular glycosphingolipid is collected from a marine sponge Agelas mauritianus.

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