Novel glycosyl sulfotransferases gst-4.alpha., gst-4.beta.,...

Details Novel glycosyl sulfotransferases gst-4.alpha., gst-4.beta.,... Novel glycosyl sulfotransferases gst-4.alpha., gst-4.beta.,...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C12N 1/20 (2006.01) C12N 9/10 (2006.01) C12N 9/18 (2006.01) C12N 15/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2378026

Novel glycosyl sulfotransferases (GST-4.alpha., GST-4.beta., and GST-6) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including various diagnostic and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-4.alpha., GST-4.beta., and GST-6.

L'invention concerne de nouvelles glycosylsulfotransférases (GST-4.alpha., GST-4.beta. et GST-6) et des polypeptides apparentés, ainsi que des compositions d'acides nucléiques les codant. Ces polypeptides et ces compositions d'acides nucléiques peuvent être mis en application dans une variété de domaines, y compris la recherche, le diagnostic et la détection d'agents thérapeutiques. Elle concerne également des procédés permettant d'inhiber des épisodes de fixation par l'intermédiaire de sélectine et des procédés servant à traiter des maladies associées à ceux-ci, en particulier par administration d'un inhibiteur d'au moins un de GST-4.alpha., GST-4.beta. et GST-6.

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