Novel has2 splicing variant hoefc11: a target in chronic...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/52 (2006.01) A61K 31/70 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 9/00 (2006.01) C12N 9/10 (2006.01) C12Q 1/25 (2006.01) C12Q 1/68 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2231723

HOEFC11 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing HOEFC11 polypeptides and polynucleotides in the design of protocols for the treatment of chronic renal failure, inflammatory diseases, myocardial ischemia, cancer, rheumatoid arthritis, cirrhotic liver disease, among others, and diagnostic assays for such conditions.

Sont décrits des polypeptides HOEFC11, des polynucléotides et des méthodes de production de tels polypeptides par des techniques recombinantes. Sont également décrites des méthodes dans lesquelles sont utilisés les polypeptides HOEFC11 et les polynucléotides pour l'établissement de protocoles pour le traitement de l'insuffisance rénale chronique, des maladies inflammatoires, de l'ischémie myocardiaque, du cancer, de la polyarthrite rhumatoïde et de la cirrhose du foie, parmi d'autres, ainsi que pour le diagnostic de telles maladies.

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