C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/475 (2006.01) A61K 38/18 (2006.01) C07K 14/435 (2006.01) C07K 14/46 (2006.01) C07K 14/47 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2267106
The present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a GCF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.
L'invention concerne deux nouveaux polypeptides, désignés par les termes de fragments hérissons N et C, ou de fragments N-terminal ou C-terminal, respectivement, qui sont obtenus par clivage spécifique au niveau du site G?CF reconnu par le domaine auto-protéolytique de la protéine native. L'invention concerne également des polypeptides hérissons modifiés par un stérol, ainsi que leurs fragments fonctionnels. Elle concerne enfin des méthodes permettant d'identifier des compositions qui modifient l'activité hérisson en inhibant la modification par le cholestérol de la protéine hérisson.
Beachy Philip A.
Porter Jeffrey A.
Mbm Intellectual Property Law Llp
The Johns Hopkins University School Of Medicine
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