C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/864 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/35 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2418442
The present invention provides methods and compositions for preparations of recombinant parvovirus virions with a reduced number of replication competent particles. The compositions of the present invention include nucleic acids encoding parvovirus helper functions which contain at least one non-native intron sequence. The present invention also includes helper function vectors, host cells transfected with the helper function vectors, methods of using the helper function vectors, and recombinant parvovirus virions produced by such methods.
L'invention concerne des procédés et compositions servant à préparer des virions de parvovirus recombiné, à l'aide d'un nombre réduit de particules de réplication compétentes. Les compositions selon l'invention comprennent des acides nucléiques codant les fonctions auxiliaires du parvovirus, lesquelles comprennent au moins une séquence d'intron non naturel. L'invention concerne encore des vecteurs de fonctions auxiliaires, des cellules hôtes transfectées à l'aide de ces vecteurs, des procédés d'utilisation de ces vecteurs de fonctions auxiliaires, ainsi que des virions de parvovirus recombiné, produits à l'aide de tels procédés.
Cao Lei
During Matthew J.
Xiao Weidong
Neurologix Inc.
Riches Mckenzie & Herbert Llp
Thomas Jefferson University
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