Novel heparin binding peptides

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/08 (2006.01) A61K 38/10 (2006.01) A61K 38/28 (2006.01) C07K 14/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2257614

The present invention provides heparin antagonist peptides. The heparin- binding peptides of the present invention specifically neutralize heparin's conventional anticoagulant properties without causing deleterious hemodynamic side effects or exacerbation of the proliferative vascular response to injury. More specifically, the heparin-binding compounds of the present invention are short-duration drugs to be used in elective or emergency situations which can safely and specifically neutralize heparin's conventional anticoagulant properties without causing deleterious hemodynamic side effets or exacerbation of the proliferative vascular response to injury.

La présente invention concerne des peptides antagonistes de l'héparine qui se lient à l'héparine et neutralisent de façon spécifique les propriétés conventionnelles d'anticoagulant sans entraîner d'effets secondaires hémodynamiques nocifs ni d'exacerbation de réponse vasculaire proliférante sur la lésion. De façon plus spécifique, les composés se liant à l'héparine de la présente invention sont des médicaments à action courte durée s'utilisant dans des situations provoquées ou dans des situations d'urgence, et qui sont capables de neutraliser en toute sécurité et de façon spécifique les propriétés conventionnelles d'anticoagulant sans entraîner d'effets secondaires hémodynamiques nocifs ni d'exacerbation de réponse vasculaire proliférante sur la lésion.

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