Novel hepatocyte-like cells and hepatoblast-like cells...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 5/071 (2010.01) C12N 5/0735 (2010.01) A61K 35/12 (2006.01) A61P 1/16 (2006.01)

Patent

CA 2654130

The present invention relates to a novel hepatocyte-like cell population derived from hBS cells and to the potential use of such heopatocyte-like cells in e.g. medical treatment, drug screening and toxicity testing. Furthermore, the invention relates to hepatoblast-like cells that may have suitable characteristics so that they can be used for the same applications as the hepatocyte-like cells and that furthermore may be used in in vitro studies of hepatogenesis such as early hepatogenesis or hepato-regenerative disorders. Both the hepatocyte-like and the hepatoblast-like cells according to the invention express drug transporter and/or drug metabolising characteristics either at the gene or protein expression level.

La présente invention concerne une nouvelle population de cellules de type hépatocytes dérivée de cellules hBS, ainsi que l'utilisation potentielle de telles cellules de type hépatocytes dans le cadre par exemple d'un traitement médical, du criblage de médicaments ou d'essais de toxicité. L'invention concerne en outre des cellules de type hépatoblastes susceptibles de présenter des caractéristiques appropriées pour pouvoir être utilisées dans les mêmes applications que les cellules de type hépatocytes, lesdites cellules de type hépatoblastes pouvant être en outre utilisées dans des études in vitro de l'hépatogenèse, par exemple de l'hépatogenèse précoce ou des troubles hépato-régénératifs. Les cellules de type hépatocytes et les cellules de type hépatoblastes de l'invention expriment des caractéristiques de transport de médicament et/ou de métabolisme de médicament au niveau d'expression du gène ou de la protéine.

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