C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 417/04 (2006.01) A61K 31/4439 (2006.01) A61P 27/02 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2696016
The present invention relates to novel compounds of Formula (I), wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, M1, M2, M3, A m, B n are defined in Formula (I), invention compounds are modulators of metabotropic glutamate receptors - subtype 4 ("mGluR4") which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.
L'invention concerne de nouveaux composés de formule (I). X1, X2, X3, X4, Y1, Y2, Y3, Y4, M1, M2, M3, Am et Bn sont définis dans les revendications de l'invention. Les composés de l'invention sont des modulateurs des récepteurs métabotropiques du glutamate de sous-type 4 ("mGluR4") qui servent à traiter ou à prévenir des troubles du système nerveux ainsi que d'autres troubles modulés par les récepteurs mGluR4. L'invention concerne également des compositions pharmaceutiques associées et un procédé d'utilisation de tels composés servant à fabriquer des médicaments, ainsi qu'un procédé d'utilisation de tels composés visant à prévenir et à traiter des maladies dans lesquelles mGluR4 est impliqué.
Bolea Christelle
Celanire Sylvain
Addex Pharma S.a.
Smart & Biggar
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