Novel heteroaryl derivatives, their preparation and use

Details Novel heteroaryl derivatives, their preparation and use Novel heteroaryl derivatives, their preparation and use

C - Chemistry, Metallurgy

07

D

C07D 405/04 (2006.01) A61K 31/381 (2006.01) A61K 31/496 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07D 307/79 (2006.01) C07D 319/18 (2006.01) C07D 333/54 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2395984

A heteroaryl derivative having the formula (I) any of its enantiomers or any mixture thereof, or an acid addition salt thereof , wherein X is -O-, -S-, or - CR4R5-; and Y is -CR6R7-, -CR6R7-CR8R9-, or -CR6=CR7-; or X and Y together form a group -CR4=CR5-, or -CR4=CR5-CR6R7-; Z is -O-, or -S-; W is N, C, or CH; n is 2, 3, 4, 5, 6, 7, 8, 9 or 10; m is 2 or 3: A is O or S wherein the dotted lines mean an optional bond. The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disorders, and neurological disorders such as psychosis.

La présente invention concerne un dérivé d'hétéroaryle de formule (I), chacun de ses énantiomères ou tout mélange de ces derniers, ou un sel d'addition d'acide de ces substances. Dans ladite formule, X représente -O-, -S-, ou -CR?4¿R?5¿-; et Y représente -CR?6¿R?7¿-, -CR?6¿R?7¿-CR?8¿R?9¿-, ou -CR?6¿=CR?7¿-; ou bien X et Y forment ensemble un groupe -CR?4¿=CR?5¿-, ou -CR?4¿=CR?5¿-CR?6¿R?7¿-; Z représente -O-, ou -S-; W représente N, C, ou CH; n représente 2, 3, 4, 5, 6, 7, 8, 9 ou 10; m représente 2 ou 3; A représente O ou S, les lignes en pointillé représentant une liaison éventuelle. Les composés selon la présente invention sont considérés utiles pour le traitement de troubles affectifs tels que l'angoisse, la panique, les troubles obsessionnels-compulsifs, la dépression, la phobie sociale et les troubles de l'alimentation, ainsi que les troubles neurologiques tels que la psychose.

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