C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 213/79 (2006.01) A61K 31/4427 (2006.01) A61K 31/4439 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 213/81 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01)
Patent
CA 2644425
The invention provides novel heteroaryl-substituted arylaminopyridine derivative MEK inhibitors of Formula (Ia) Formula (Ia) Such compounds are MEK inhibitors that are useful in the treatment of hyperproliferative diseases, such as cancer and inflammation. Also disclosed is the treatment of a hyperproliferative disease in mammals, and pharmaceutical compositions containing such compounds.
L'invention concerne des inhibiteurs de MEK contenant des dérivés d'arylaminopyridine substitués par un hétéroaryle de formule (1a). Ces composés sont des inhibiteurs de MEK utilisés pour traiter des maladies hyperprolifératives, comme le cancer et des inflammations. Cette invention a aussi pour objet le traitement d'une maladie hyperproliférative chez des mammifères, ainsi que des compositions contenant ces composés.
Askew Benny C. Jr.
Chen Xiaoling
Goutopoulos Andreas
Karra Srinivasa
Yu Henry
Kirby Eades Gale Baker
Laboratoires Serono S.a.
Merck Serono Sa
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