C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/26 (2006.01) A61K 31/505 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01)
Patent
CA 2637631
The present invention relates to novel heterocyclic compounds of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and compositions, metabolites and prodrugs thereof. The present invention more particularly provides novel hetereocycles of the general formula (I). Also included is a method of treatment of immunological diseases, inflammation, pain disorder, rheumatoid arthritis; osteoporosis; multiple myeloma; uveititis; acute and chronic myelogenous leukemia; ischemic heart disease; atherosclerosis; cancer; ischemic-induced cell damage; pancreatic beta cell destruction; osteoarthritis; rheumatoid spondylitis; gouty arthritis; inflammatory bowel disease; adult respiratory distress syndrome (ARDS); psoriasis; Crohn's disease; allergic rhinitis; ulcerative colitis; anaphylaxis; contact dermatitis; muscle degeneration; cachexia; asthma; bone resorption diseases; ischemia reperfusion injury; brain trauma; multiple sclerosis; sepsis; septic shock; toxic shock syndrome; fever, and myalgias due to infection in a mammal comprising administering an effective amount of a compound of formula (I) as described above.
L'invention concerne de nouveaux composés hétérocycliques de formule générale (I), leurs dérivés, analogues, formes tautomères, stéréoisomères, polymorphes, hydrates, solvates, sels et compositions pharmaceutiquement acceptables, métabolites et promédicaments de ces composés. L'invention concerne plus particulièrement de nouveaux hétérocycles de formule générale (I). L'invention concerne en outre un procédé de traitement de maladies immunologiques, inflammation, troubles dus à la douleur, polyarthrite rhumatoïde; ostéoporose, myélome multiple; uvéite; leucémie myélogène aiguë ou chronique; maladies cardiaques ischémiques; athérosclérose; cancer; dégâts cellulaires ischémiques; destruction cellulaire; destruction cellules bêta pancréatiques; ostéoarthrite; spondylitis rhumatoïde; arthrite goutteuse; inflammation de l'intestin; syndrome de détresse respiratoire aigu (ARDS); psoriasis, maladie de Crohn; rhinite allergique; rectocolite hémorragique; anaphhylaxie; desmatite par contact; dégénérescence musculaire; cachéxie; asthme; maladies de résorption osseuse; lésion ischémique reperfusion; traumatisme cranien; sclérose en plaques; sepsis; choc septique; syndrome choc toxique; fièvre; myalgie due à une infection chez un mammifère, ledit procédé comprenant l'administration d'une quantité efficace d'un composé de formule (I) tel que précédemment décrit.
Bhakiaraj Durairaj Peter
Janarthanam Venkatesan
Kachhadia Virendra
Narayanan Sukunath
Narsimhan Kilambi
Gowling Lafleur Henderson Llp
Orchid Research Laboratories Limited
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