Novel heterocyclic amide compound and pharmaceutical use...

C - Chemistry – Metallurgy – 07 – D

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C07D 413/12 (2006.01) A61K 31/505 (2006.01) C07D 239/47 (2006.01) C07D 417/12 (2006.01) C07D 498/04 (2006.01) C07K 5/04 (2006.01)

Patent

CA 2269720

Heterocyclic amide compounds represented by general formula (I) or pharmacologically acceptable salts thereof; medicinal compositions thereof; and medicinal uses of the same wherein each symbol is as defined in the specification. These compounds and pharmacologically acceptable salts thereof have excellent effects of inhibiting chymases on mammals including human being and can be administered orally or parenterally. Thus, they are useful as chymase inhibitors in preventing and treating various diseases caused by chymases typified by those caused by angiotensin II.

L'invention concerne des composés d'amide hétérocycliques représentés par la formule générale (I) ou des sels pharmaceutiquement acceptables desdits composés, ainsi que des compositions médicinales contenant lesdits composés et leur utilisation à des fins médicinales. Dans la formule (I), la signification de chaque symbole est donnée dans la description. Ces composés et leurs sels pharmaceutiquement acceptables présentent d'excellents effets inhibiteurs sur les chymases chez les mammifères y compris chez l'homme, et peuvent être administrés par voie orale ou parentérale. Par conséquent, ils s'utilisent comme inhibiteurs de chymases pour prévenir et traiter différentes maladies provoquées par des chymases, par ex. les maladies provoquées par l'angiotensine II.

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