C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 495/04 (2006.01) A61K 31/137 (2006.01) A61K 31/33 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) A61K 47/44 (2006.01) A61K 51/00 (2006.01) A61P 13/12 (2006.01) A61P 25/18 (2006.01) C07D 261/20 (2006.01) C07D 333/36 (2006.01) C07D 333/58 (2006.01) C07D 333/66 (2006.01) C07D 333/68 (2006.01) C07D 409/04 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 451/02 (2006.01) C07D 471/04
Patent
CA 2438318
The invention relates to heterocyclic substituted amide derivatives of formula (I) that display selective binding to dopamine D3 receptors. In another aspect, the invention relates to a method for treating central nervous system disorders associated with the dopamine D3 receptor activity in a patient in need of such treatment comprising administering to the subject a therapeutically effective amount of said compounds for alleviation of such disorder. The central nervous system disorders that may be treated with these compounds include Psychotic Disorders, Substance Dependence, Substance Abuse, Dyskinetic Disorders (e.g. Parkinson's Disease, Parkinsonism, Neuroleptic- Induced Tardive Dyskinesia, Gilles de la Tourette Syndrome and Huntington's Disease), Dementia, Anxiety Disorders, Sleep Disorders, Circadian Rhythm Disorders and Mood Disorders. The subject invention is also directed towards processes for the preparation of the compounds described herein as well as methods for making and using the compounds as imaging agents for dopamine D3 receptors.
L'invention porte sur des dérivés hétérocycliques d'amides substitués se fixant sélectivement aux récepteurs de la dopamine D¿3?, et sur un procédé de traitement de troubles du SNC associés à l'activité dudit récepteur chez des patients le nécessitant, consistant à leur administrer une dose à effet thérapeutique desdits composés pour atténuer les troubles. Les troubles du SNC susceptibles d'être traités par ces composés comprennent: les troubles psychotiques, la dépendance vis à vis de substance, l'abus de substances, les troubles dyskinésiques (par exemple maladie de Parkinson, parkinsonisme, dyskinésie tardive induite par neuroleptiques, syndrome de Gilles de la Tourette, maladie de Huntington), la démence, l'angoisse, les insomnies, les troubles du rythme circadien et les troubles de l'humeur. L'invention porte également sur des procédés de préparation desdits composés, et sur leur fabrication et leur utilisation comme agents de mise en évidence des récepteurs de la dopamine D¿3?.
Bordeau Kenneth J.
Gill Harpal
Hemmerle Horst
Hendrix James A.
Jackson Sharon A.
Aventis Pharmaceuticals Inc.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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