Novel heterocyclic compounds

Details Novel heterocyclic compounds Novel heterocyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) C07D 273/01 (2006.01) C07D 321/12 (2006.01) C07D 405/12 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2231835

A compound of formula (I), wherein R1 and R2 independently are hydrogen, halogen, trifluoromethyl, hydroxy, C1-6-alkyl or C1-6-alkoxy; and R3 is hydrogen or C1-3-alkyl; and A is C1-3-alkylene; and Y is ><u>C</u>H-CH2-, ><u>C</u>=CH-, ><u>C</u>H-O-, ><u>C</u>=N-, ><u>N</u>-CH2- wherein only the underscored atom participates in the ring system, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

L'invention porte sur un composé répondant à la formule (I) dans laquelle R<1> et R<2> représentent, indépendamment, un hydrogène, un halogène, un trifluorométhyle, un hydroxy, un C1-C6 alkyle ou un C1-C6 alkoxy et R<3> représente un hydrogène ou un C1-C3 alkyle, A représentant un C1-C3 alkylène tandis que Y représente ><u>C</u>H-CH2-, ><u>C</u>=CH-, ><u>C</u>H-O-, ><u>C</u>=N-, ><u>N</u>-CH2-, seul l'atome souligné participant au système cyclique. Cette invention porte également sur des procédés de préparation de ces composés, sur des compositions les contenant, ainsi que sur leur application pour le traitement clinique de manifestations douloureuses, hyperalgésiques et/ou inflammatoires dans lesquelles des fibres C jouent un rôle physiopathologique en déclenchant douleur ou inflammation.

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