C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/24 (2006.01) A61K 31/195 (2006.01) A61K 31/33 (2006.01) C07C 229/56 (2006.01) C07D 223/28 (2006.01) C07D 267/16 (2006.01) C07D 281/12 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2217198
A compound of formula (I), in which Z is selected from (a), (b), (c) and (d). The present invention relates to novel N-substituted amino acids and esters thereof in which a substituted alkyl chain forms part of the N-substituent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
La présente invention décrit un composé de formule (I). Z est choisi parmi des composés de formule (a), (b), (c) et (d). La présente invention se rapporte à de nouveaux aminoacides N substitués et leurs esters dans lesquels une chaîne alkyle substituée fait partie du substituant N ou de ses sels, à leur procédé de fabrication, aux compositions les contenant et à leur utilisation pour le traitement clinique des états douloureux, hyperalgésiques et/ou inflammatoires dans lesquels les fibres C jouent un rôle pathophysiologique en induisant une douleur ou inflammation neurogène.
Andersen Henrik Sune
Andersen Knud Erik
Dorwald Florenzio Zaragossa
Hohlweg Rolf
Jorgensen Tine Krogh
Mccarthy Tetrault Llp
Novo Nordisk A/s
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