Novel heterocyclic compounds

Details Novel heterocyclic compounds Novel heterocyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 417/06 (2006.01) A61K 31/451 (2006.01) A61K 31/4523 (2006.01) A61K 31/473 (2006.01) A61K 31/538 (2006.01) A61K 31/5415 (2006.01) A61K 31/55 (2006.01) A61K 31/551 (2006.01) C07D 207/08 (2006.01) C07D 211/60 (2006.01) C07D 211/78 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01)

Patent

CA 2180238

The present invention relates to novel N-substituted azahetero- cyclic carboxylic acids and esters thereof (I) in which a substituted alkyl chain forms part of the N-substitutent or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory condition in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.

L'invention concerne de nouveaux acides carboxyliques azahétérocycliques substitués en N et leurs esters de la formule (I), dans laquelle une chaîne alkyle substitué fait partie intégrante du substituant en N ou de ses sels. L'invention concerne en outre des procédés permettant de préparer ces composés, des compositions les contenant, ainsi que leur utilisation dans le traitement clinique d'états douloureux, des hyperalgésies et/ou des états inflammatoires, dans lesquels les fibres de type C ont un rôle déterminant en terme de pathophysiologie, dans la mesure où elles induisent la douleur ou l'inflammation neurogène.

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